Biofreeze is the pain reliever of choice for chiropractors, podiatrists, physical therapists, occupational therapists, massage therapists and athletic trainers. Biofreeze contains an herbal extract from a South American holly shrub known as ILEX to create a fast-acting, deep-penetrating, long-lasting pain reliever. It’s critical for treating : Sore or strained muscles, shoulder/arm discomfort, neck, hip and leg pain, back pain, arthritis pain, and painful joints.