Can be used as often as necessary – up to 4 times per day. The application can be applied pre-treatment to acute areas of muscle spasms to allow for a faster relaxation of muscle involvement and better treatment response. The roll-on is also a convenient application for the patient at home to continue care for these acute conditions. As a roll-on it also affords the office staff a very hygienic delivery system for applying Biofreeze to the patients.